β-amyloid induces a dying-back process and remote trans-synaptic alterations in a microfluidic-based reconstructed neuronal network

screen-shot-2016-10-18-at-21-41-16Recent histopathological studies have shown that neurodegenerative processes in Alzheimer’s and Parkinson’s Disease develop along neuronal networks and that hallmarks could propagate trans-synaptically through neuronal pathways. The underlying molecular mechanisms are still unknown, and investigations have been impeded by the complexity of brain connectivity and the need for experimental models allowing a fine manipulation of the local microenvironment at the subcellular level.

Bérangère Deleglise1,2,3,4†, Sebastien Magnifico3,4†, Eric Duplus1,2,3,4, Pauline Vaur1,2,4, Vanessa Soubeyre3,4, Morgane Belle3,4, Maeva Vignes3,4,5,6, Jean-Louis Viovy5,6, Etienne Jacotot1,2,4,7, Jean-Michel Peyrin1,2,3,4 and Bernard Brugg1,2,3,4*

deleglise-et-al-2014-published-acta-neuropathol-com